Open symposium in Sugiyama’s Laboratory
“Recent Development and Perspective of DMPK Research”
Co-organized by APSTJ Global Education Seminar
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Time and Venue
Date: June 16 (Tue): 12:30-17:45
Venue: Riken Yokohama Koryu-toh
Program
12:30-13:10 (30+10) Ronald S Obach (Pfizer)
Recent Challenges in Predicting Drug Metabolism and How We Are Trying to Solve Them
13:10-13:50 (30+10) Amit Kalgutkar (Pfizer)
Toxicophores in Drug Design: Potential for “Trouble”?
13:50-14:30 (30+10) Peter Bonate (Astellas)
“Compound selection based on PK/PD modeling in oncology”
14:30-15:10 (30+10) Yuichi Sugiyama (RIKEN)
Prediction of complex DDI from in vitro data on metabolism and transport
15:10-15:30 Break
15:30-15:50 (15+5) Sumito Ito and Satoshi Senda (Genomembrane)
Joint Project with RIKEN Sugiyama’s Lab:
Establishment of the transporter expression system for drug-induced tissue(hepatic and renal) injury prediction
15:50-16:15 (15+10) Yoshihisa Shitara (Meiji Seika Pharma)
Kinetic analysis of time dependent inhibition of cyclosporin A for OATP1B1 mediated hepatic uptake of substrates
16:15-16:40 (15+10) Saki Izumi and Yoshitane Nozaki (Eisai)
Impact of substrate selection on in vitro OATP1B1 inhibition profiles for the prediction of DDIs
16:40-17:05 (15+10) Tomohisa Nakada (Mitsubishi Tanabe Pharma)
Estimation of unbound intracellular–medium(plasma) concentration ratios (Kpuu) of Poorly-Metabolised Anionic Drugs Using Rat and Human Hepatocytes
17:05- 17:30 (15+10) Ryuta Asaumi (Ono Pharma)
Establishment of rifampicin PBPK modeling which predicts all kinds of interactions including induction / inhibition of enzymes and transporters.
17:30-17:45 Concluding remarks
Ronald S Obach, Yuichi Sugiyama,
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参加申込締切： 6月9日（火）12時まで